Guttoxconsult

Curriculum Vitae                                                                 

                                                            Joseph B. Guttenplan

Home Address:                                  110 E. Brookside Drive

Larchmont, New York 10538

Office Address:                     New York University Dental and Medical Schools

                                                Depts. of Basic Science, and Environmental Medicine

345 East 24^th St.

New York, New York 10010

Web Site                                www.guttoxconsult.com

Education:                

1961-1965                               B.S.                 Brooklyn College

1965-1970                               Ph.D., M.S.     Brandeis University - Chemistry

1989-1991                               M.P.H.                        Columbia University School of Public Health

Postgraduate Training and Fellowship Appointments:

1969-1971       Max Planck Institut fuer Spektroskopie, Goettingen, Germany, Advisor, Dr. Albert Weller

1971-1973       University of California, Berkeley, CA, Advisor, Dr. Melvin Calvin

Faculty Appointments:

1973-1974       Research Assistant Professor of Biochemistry 

Mount Sinai School of Medicine, New York, NY

1974-1978       Assistant Professor of Biochemistry

N.Y. University Dental Center, New York, NY

1978-1987       Associate Professor of Biochemistry

N.Y. University Dental Center, New York, NY

1980-1984       Consultant, Mount Sinai School of Medicine,

                                    Dept. of Medicine, New York, NY

1983-Present   Assoc. Prof. Environmental Medicine (p.t.)

New York University School of Medicine, New York, NY

1987-Present   Professor of Biochemistry

New York University School of Dentistry, New York, NY

1991-1999       Coordinator, Biochemistry & Microbiology Unit

New York University School of Dentistry, NewYork, NY

1993-2000       Director, Office of Research

New York University School of Dentistry, New, York, NY

Courses taught : biochemistry, mutagenesis and DNA repair, genetic toxicology, molecular toxicology, proteins, enzymes

Non-academic employment:

1982-Present:   Private consultant in toxicology

Types of damages: cancer, birth defects, intoxication, kidney disease, lung disease, reactive airway disease, nervous system damage, multiple chemical sensitivity syndrome, asthma, heart disease, genital injury, drug-induced hair loss.

Types of toxic agents: e-cigarettes, ionizing radiation, toxic waste dumps, insecticides, dioxin, toxic dyes, environmental tobacco smoke, antiviral drugs, floor cleaning solutions, alcohol, carbon monoxide,  asbestos, wood preservative, glue vapors, pesticides, insecticides, automobile parts washer solvent, lithium overdose, toxic gas release from chemical plant, toxic gases from sewage plant, toxic chemicals at a railroad site, analysis of test data on predicting birth defects, metal fumes, oil refinery chemicals, personal lubricant toxic effects, carcinogens at a water treatment plant, carcinogens at a titanium dioxide plant.

Depositions and court appearances (types of cases – case names omitted)

·         Possible carcinogenic effects of swimming pool testing dye (defense)

·         Automotive parts cleaning solution and paralysis (plaintiff) case 1

·         Automotive parts cleaning solution and paralysis (plaintiff) case 2

·         Chlorine exposure at a water treatment plant (defense)

·         Lithium overdose and mental impairment (plaintiff)

·         Alcohol intoxication and automobile accident (defense)

·         Dioxin and arsenic exposure as a cause of cancer (plaintiff)

·         Personal lubricant and genital injury (defense)

Awards and Honors:

1961-65                       N.Y. Regents Scholarship

1965-69                       National Defense Education Act Title IV Fellowship

1969-71                       Max Planck Institute Stipendium

1971-72                       N.I.H. Postdoctoral Fellow

1972-73                       N.I.H. Special Fellow

Areas of research expertise

·         Cancer causation

·         Tobacco carcinogens

·         Mechanisms of mutagenesis and carcinogenesis

·         Genotoxicity of estrogen metabolites in vitro and in vivo

·         In vivo mutagenesis induced by exogenous and endogenous carcinogens in lac rodent organs: lung, oral cavity, esophagus, breast, colon, liver

·         Chemoprevention of mutagenesis by dietary and related agents in vivo in lac rodents

·         Development of a flourescent DNA post-labeling assay

·         Measurement of DNA adducts induced by tobacco carcinogens and oxidative stress

·         Spontaneous mutagenesis

·         Measurement of metabolism of carcinogens

Professional activities

·         Member editorial boards, “Mutation Research”, “Nutrition and Cancer”

·         Nominee for president of Carcinogenesis section of Society of Toxicology

·         Member of scientific advisory group to the World Trade Association Panel on Hormone-       Treated Beef (2006)

·         Member of site visit team to University of Cincinnati Medical Center for NIH, 2002

·         Member NIEHS and EPA Special Study Section for Superfund Basic Research Grant Applications (1988).

·         Grant reviewer for the Medical Research Council of Canada (ad hoc)

·         Invited speaker at meetings: 9^th International Conference of Anticancer Research, 16^th Heidelberger Symposium, NYU College of Medicine, 2007, AAAS Southwestern Meeting, 2006, Era of Hope, 2005, NIH focus group, Cancer Cube, 2002, 3rd International Conference on Smokeless Tobacco, 2002, 4^th Chemical Congress of North America & 202 ACS National Meeting, 1991, Mount Sinai Medical Center, Dept of Medicine Minicourse on Enzyme Kinetics 1985, Hoffman LaRoche, Meeting on Inhibition of Carcinogenesis by Vitamins, 1980

·         Summer Faculty Research Fellow, Air Force Office of Scientific Research, Dayton, OH (1995)

·         Chaired scientific sessions at the 2010 American Association for Cancer Research Annual Meeting, 8th Int. Conf. On Environmental Mutagens (2001) AADR/IADR Annual Meeting (1999), the International Environmental Mutagenesis Meeting (1989), the Environmental Mutagen Society National Meeting (1982).

·         Visiting Scientist, NIH Rocky Mountain Laboratory (1988)

·         Member of NIH site visit team to Eppley Cancer Research Institute, 1986

·         Fellow, The American Institute of Chemists

·         Reviewer (ad hoc, partial list): Science, Proc.Nat.Acad.Sci., Cancer Research, Carcinogenesis, Biochemistry, Environmental and Molecular Mutagenesis, Mutation Research, Biochemical Toxicology, Nutrition and Cancer, Int. J. Oncology

·         Listed in Several of the Marquis volumes including: Who’s Who in America and Who’s Who in Science and Technology

·         Invited talks (partial list): Penn State Medical School, University of California, Santa Cruz; Syntax Corp., San Jose, CA; Mount Sinai Medical Center, New York, NY; Dept. of Environmental Medicine, NYU Medical Center Sterling Forest, NY (two different occasions); City College of CUNY, New York, NY (two different occasions); FMC Corp., Trenton, NJ; Hoffman LaRoche, Nutley, NJ; NIH-Rocky Mountain Laboratory, Hamilton, MO; Queens College of CUNY, Queens, NY; York University (Canada), Univ. of Dentistry and Medicine, Newark, New Jersey; Staten Island College of CUNY, Staten Island, NY.

·         Outside reader for  Ph.D. thesis defenses at NYU Medical School (several times); Mount Sinai Medical Center; York University, Toronto, Canada

·         Memberships in Professional and Scientific Societies:

·         Society of Toxicology, AAAS, American Association Cancer Research, Environmental Mutagen Society, American Society of Molecular Biology and Biological Chemists (currently inactive), AADR/IADR, American Institute of Chemists (currently inactive), American Chemical Society (currently inactive)

Research Grants

·         NIH  CA173465        04/01/13 - 3/31/18    CoI

Chemoprevention by black raspberry in oral cancer induced by DB[a,l]P in mice (P.I.  Dr.  K. El Bayoumy.

·         Colgate 08/01/2013 – 07/31/2014 PI 

Effects of oral healthcare products on oxidative stress in a model system, and in human oral cells.

·         NIH CA118397        8/1/2006 – 7/31/2008.

      Mutagenicity of tobacco smoke in human cell co-cultures, $275,000 TDC, PI

·         Susan Komen Breast Cancer Foundation  7/15/2008 – 7/14/2111.

      Combination chemoprevention of mutagenesis and related endpoints in mammary epithelial           cells and rat mammary tissue,  $600,000,  PI

·         DOD BC022345       7/1/03 B 6/30/07  $180,000 total cost/yr

      Estrogen-Induced Depurination of DNA: a Novel Target for Breast Cancer Prevention.

      Center of Excellence Award. J.G is P.I. on project 3.

·         NIH CA 099146        4/1/04 B 3/31/07  $73,500/ total/yr

      Origins of Spontaneous Mutagenesis, PI

·         NIH  4/1/03 B 3/31/06  $46,000 total/yr                   

      Etiology and Prevention of Oral Cancer (P.I., K. El Bayoumy)

·         NIH  CA35519         4/1/02 - 3/31/06    $52,000 total/yr                                                           Breast Cancer Induction by Nitrochrysene (P.I.  Dr.  K. El Bayoumy)

·          National Cancer Institute, RO1, Antimutagenesis by Lycopene and Selenium in lacZ mice in vivo, $593,000 (total costs) (8/98 - 8/01)

·         Smokeless Tobacco Research Council,  Smokeless Tobacco and  Tobacco Nitrosamines: Effects on lacZ mice, $274,000 (7/98 - 7/01)

·         Tobacco Use and Oral Cancer: Etiology and Prevention, PO1, NIDCR, 1999-2002, Part of Project #3, $40,000, yr.1 (9/99-8/00)

·         Am. Inst. for Cancer Research, Dietary-Agent Inhibition of Mutagenesis in Lac Transgenic Mice, $165,000, (1/96 -12/98)      

·         NIH-DE0117, RO3, Smokeless Tobacco and Human Oral Tissue, $75,000 (8/94-7/96)

·         Air Force Office of Scientific Research Grant, $25,000 (1996)

·         NIH‑CA44986, RO1, Mutagenic Components in Smokeless Tobacco, $305,144 (1987‑1991)

·         NIH-NIEHS, RO1, ES03332, Mechanisms of Carcinogenesis and Mutagenesis, $372,947 (1983‑1986)

·         NIH‑CA19023, RO1, Mechanisms of Carcinogenesis and Mutagenesis;$195,689 (1979‑1982)

·         NIH‑CA19023, RO1, Mechanisms of Carcinogenesis $151,356 (1976

·         Coinvestigator on:

·         Chemical Induction of Prostate Adenocarcinoma (M. Bosland, P.I.), NCI, 1989- 1994,

·         Minority Oral Center, Phase I, NIDR (R. LeGeros, P.I.) 1992-1995,

·         Mechanisms of Cisplatin Nephrotoxicity (R. Safirstein, P.I., 1980-1984)

·         Numerous institutional grants including two Research Challenge Fund awards, an award from the NYU Medical Center Institutional American Cancer Society Grant and several faculty research awards from NYUCD

Ph.D and M.S. Mentorships:

Ph.D. Joanne Zurlo, 1980, Warren Snyder, 1980, Sam Milstein, 1983, Madeline Castle, 1991, Joan Fliessbach, 1993, Bill Drosopoulos, 1993.

M.S. Susanne Lee, 1982, Joan Fliessbach, 1984, Marcia von Pressentin,1999.

Bibliography:

BOOK: Biochemistry, Sulzberger & Graham, New York, NY, 1994 (Coauthor with Dr. M. Oratz) .

Scientific Articles

Cohen, S.G., and Guttenplan, J.B.,  Photoreduction of Fluorenone by Amines: Medium Effects.  Tet Letters, 51, 5353-5356 (1968).

Guttenplan, J.B., and Cohen, S.G., Aliphatic Sulfides:  Physical Quenchers and Photoreducing Agents,  Chem. Comm. 247-249, (1969).

Guttenplan, J.B., and Cohen, S.G.,  Photoreduction of Fluorenone by Amines:  Effect of Medium on Intersystem Crossing,  Tet Letters, 52, 2125-2129, (1969).

Cohen, S.G., Guttenplan, J.B., and Salzmann, M.:, Para‑aminobenzophenone: Medium Effects on Intersystem crossing,  Tet Letters, 52, 4321-4323, (1969).

Guttenplan, J.B., and Cohen, S.G.,  Triplet Energies, Reduction Potentials and Ionization Potentials in Carbonyl‑Donor Partial Charge‑Transfer Interactions.  I.,  J. Amer. Chem.  Soc.  94, 4040-4042, (1972).

Guttenplan, J.B., and Cohen, S.G., Triplet Energies, Reduction Potentials and Ionization Potentials in Carbonyl‑Donor Partial Charge‑Transfer Interactions. II. 55, Tet Letters 2163-2165, (1972).

Guttenplan, J.B., and Cohen, S.G.,  Excited State Complexes and Their Photochemistry:  Triplet Benzophenone and Thioethers.  J. Org. Chem., 38 (1973).

Guttenplan, J.B., and Calvin, M.,   Tertiary and Quaternary Structure of Tobacco Mosaic Virus and Protein I.  Effect of pH on Fluorescence and TNS Binding. Biochem Biophys Acta 322, 294‑300, (1973).

Guttenplan, J.B., and Calvin, M.,  Tertiary and Quaternary Structure of Tobacco Mosaic Virus and Protein II.  Emission, Excitation, Polarization and Position of TNS Binding.  Biochem Biophys Acta 322, 301‑320, (1973).

Guttenplan, J.B., Garro, A.J., and Hutterer, F.,  Effects of Enzyme Inducers on Dimethylnitrosamine Demethylase Activity and Capacity of Isolated Microsomes to Activate Dimethylnitroamine to a Mutagen.  Mutation Res 35, 415‑422 (1976).

Garro, A.J., Guttenplan, J.B., and Milvy, P.,  Vinyl Chloride Dependent Mutagenesis: Effects of Liver Extracts and Free Radicals, Mutation Res., 38, 81‑88 (1976).

Guttenplan, J.B., Garro, A.J., and Hutterer, F.,  Effects of Enzyme Inducers on Dimethylnitrosamine Demethylase Activity and Capacity of Isolated Microsomes to Activate Dimethylnitrosamine to a Mutagen.  Prev. Detect. Cancer, Proc. Int. Symp. 3rd 1(1),139‑153 (1977).

Guttenplan, J.B., and Garro, A.J., Factors Affecting the Induction of Dimethylnitrosamine Demethylase by Aroclor 1254, Cancer Res., 37, 329‑330 (1977).

Guttenplan, J.B., Inhibition by L‑Ascorbate of Bacterial Mutagenesis Induced by Two N‑Nitroso Compounds.  Nature, 268, 368‑370 (1977).

Guttenplan, J.B., Mechanisms of Inhibition by Ascorbate of Microbial Mutagenesis Induced by N‑nitroso Compounds.  Cancer Res. 38, 2018‑2022 (1978).

Guttenplan, J.B., Comutagenic Action of N‑Nitroso Compounds, Mutation Res., 66, 25‑32 (1979).

Guttenplan, J.B., Detection of Trace Amounts of Dimethylnitrosamine with a Modified Salmonella/Microsome Mutagenicity Assay.  Mutation Res., 64, 91‑94 (1979).

Milstein, S. and Guttenplan, J.B., Near Quantitative Production of Molecular Nitrogen from Metabolism of Dimethylnitrosamine, Biochem. Biophys. Res. Comm., 87, 337‑342 (1979).

Unger, J. and Guttenplan, J.B., Enhanced Sensitivity Towards Benzo(a)pyrene and its Metabolites in a Modified Salmonella/Microsome Assay, Mutation Res., 77, 221‑228 (1980).

Guttenplan, J.B., Enhanced Mutagenic Activities of N‑Nitroso Compounds in Weakly Acidic Media, Carcinogenesis, 1, 439‑444 (1980).

Activation of Promutagens by Liver Homogenates Isolated from Female Mice at Different Ages, Guttenplan, J.B., and Bliznakov, E.G., Mech. Aging and Develop., 16, 29‑35 (1981).

Fliessbach, J.H., and Guttenplan, J.B., Salivary Levels of N‑Nitrosamines and Some Metabolites after IP Injection in Rats, Res. Comm. Chem. Path. Pharm., 33, 283‑291 (1981).

Lee, S.Y. and Guttenplan, J.B., A Correlation between Mutagenic and Carcinogenic Potencies in a Diverse Group of N‑nitrosamines Determination of Mutagenic Activities of Weakly Mutagenic N‑nitrosamines, Carcinogenesis, 2, 13391334 (1981).

Guttenplan, J.B., and Milstein, S.,  On the Effect of pH on the Mutagenic Activities of N‑nitrosamines, Mutation Res. 93, 249‑250, (1982).

Guttenplan, J.B., and Milstein, S., Resistance of Salmonella typhimurium TA 1535 to O⁶‑Guanine Methylation and Mutagenesis Induced by Low Doses of N‑methyl‑N‑nitro‑N‑nitrosoguanidine, Carcinogensis 3, 327‑334 (1982).

Safirstein, R.L., Daye, M. and Guttenplan, J.B., Mutagenic Activity and Identification of Excreted Platinum in Human Rat Urine After Administration of Cisplatin, Cancer Letters, 18, 329‑338 (1983).

Scanlon, K.J., Safirstein, R.L., Thies, H., Waxman, S. and Guttenplan, J.B., Inhibition of Amino Acid Transport by Cisplatin and its Derivatives in L1210 Murine Leukemia Cells, Cancer Research, 43, 4211‑4215 (1983).

Safirstein, R.L., Miller, P., and Guttenplan, J.B., Uptake and Metabolism of Cisplatin by Rat Kidney, Kidney International, 25, 753‑758 (1984).

Guttenplan, J.B., Effects of pH and Structure on the Mutagenic Activity of N‑nitroso Compounds, in:  Topics in Chemical Mutagenesis 1, "N‑Nitrosamines" (ed. F.J.  deSerres and T.K. Rao), 59‑90, (1984), Plenum Press, NY.  (Book chapter)

Guttenplan, J.B., Mutagenesis and O⁶‑Ethylguanine Levels in DNA from N‑nitroso‑N‑ethylurea treated Salmonella typhimurium:  Mutational Efficiency of O⁶‑Ethylguanine, Carcinogenesis 5, 155‑159 (1984).

Guttenplan, J.B., and Hu, Y.C., Mutagenesis by N‑Nitroso Compounds in Salmonella typhimurium TA102 and TA 104: Evidence for Premutagenic Adenine and Thymine DNA Adducts, Mutation Res.,  141, 155‑159 (1984)

Guttenplan, J.B., and Hu, Y.C., Mutagenesis by N‑Nitroso‑N‑Ethylurea in S. typhimurium:  Evidence for a Major Premutagenic Ethyldeoxythymidine DNA‑ Adduct, Carcinogenesis 6, 1513‑1516 (1985).

Safirstein, R., Winston, J., Goldstein, M., Moel, D., Dikman, S. and Guttenplan, J.,  Cisplatin nephrotoxicity, Am‑J‑Kidney‑Dis., 8,  356‑67 (1986)

Safirstein,R., Winston, J., Moel, D., Dikman, S. and Guttenplan, J., Cisplatin nephrotoxicity: Insights into Mechanism, Int‑J‑Androl., 10, 325‑46 (1987).

Guttenplan, J.B., Structure‑Activity Relationships in á‑Oxidation and Mutagenicities of N‑nitrosomines, IARC Publication The Relevance of N‑nitroso Compounds to Human Cancer, 84, 129‑132 (1987).

Guttenplan, J.B., N‑nitrosamines:  Bacterial Mutagenesis and In Vitro Metabolism, Mutation Res., 186, 81‑134 (1987).

Guttenplan, J.B., Mutagenic Activity in Smokeless Tobacco Products Sold in the USA.  Carcinogenesis , 8 , 741‑743 (1987).

Zielenska, M. and Guttenplan, J.B., Effects of UV Repair, Error‑Prone Repair and Critical Site of Mutation on Mutagenesis Induced by N‑nitrosamines.  Mutation Res., 180, 11‑20 (1987).

Zielenska,M. and Guttenplan,J.B., Different Mutations Induced by N‑Nitroso‑N‑ Ethylurea:  Effects of Dose, and Error‑Prone DNA Repair.  Correlations with DNA Adducts, Environmental and Molecular Mutagenesis 11, 473-485 (1988).

Zielenska, M. and Guttenplan, J.B., DNA Binding by [2,5-¹⁴C] N-nitrosopyrrolidine in Excision-Repair Proficient and Deficient Strains of Salmonella.  Evidence for a Major Premutagenic Adducts, Carcinogenesis, 9, 1901-1904 (1988).

Zielenska, M. and Guttenplan, J.B., Mutagenic Activity and Specificity of N-nitrosomethylaniline and N-nitrosodiphenylamine in Salmonella, Mutation Res., 202, 269-276 (1988).

Guttenplan, J.B., An Important Role for Cytosol in the Metabolism of N-Nitrosodimethylamine to a Mutagen, Cancer Letters 47, 63-67 (1989).

Guttenplan, J.B., Mutagenesis by N-Nitroso Compounds:  Relationship to DNA Adducts, DNA Repair, and Mutational Efficiencies.  Mutation Res., 233, 177-187 (1990).

Liu, Y.X., and Guttenplan, J.B., Mutational Specificities of N-Nitrosamines in a Host-mediated Assay: Comparison with Direct-acting N-nitroso Compounds In Vitro and an Approach to Deducing the Nature of Ultimate Mutagens In Vivo, Mol. Carcinogenesis 6, 322-237 (1992)

Guttenplan, J.B., Effects of Cytosol on Mutagenesis Induced by N-nitroso-N-methylurea, á-acetoxy-N-nitrosodimethylamine, and N-nitrosodimethylamine: Evidence for two Different Ultimate Mutagens from N-nitrosodimethylamine, Carcinogenesis, 14, 1013-1019 (1993).

Guttenplan, J.B., and Kokkinakis, D., High Mutagenic Activity of N-nitrosobis(2-oxopropyl)amine and N-nitrosobis(2-hydroxypropyl)amine in the Host-mediated Assay in Hamsters: Evidence for Premutagenic Methyl and Hydroxypropyl Adducts, Carcinogen­esis, 14, 1621-1625 (1993).

Jiao, J., Guttenplan, J.B., Zielenska, M., Anderson, M.W., and Glickman, B.W., Mutational Specificities of Eenvironmental Carcinogens in the lacI gene of Escherichia coli: VI. The Host-mediated Assay and its Comparison with In Vitro Mutagenesis Induced by 4-(methyl-nitrosamino) 1-(3-pyridyl)-1-butanone, Mol. Carcinogenesis, 8, 127-131 (1993)

Chung, F.-L., Chen, H.-J.C., Guttenplan, J.B., Nishikawa, A., Hard, G.C., 2,3-Epoxy-4-hydroxynonanal as a Potential Tumor-initiating Agent of Lipid Peroxidation, Carcinogenesis, 14, 2073-2077 (1993).

Tinwell, H., Paton, D., Guttenplan, J.B., and Ashby, J. The Unexpected Genetic Toxicity to Rodents of the N',N'-dimethyl Analogues of MNU and ENU, Environ and Mol. Mutagenesis 27, 202-211 (1996).

Nath, R., Ocando, J.E., Guttenplan, J.B., and Chung, F.-L., 1,N2-Propanodeoxyguanosine Adducts: Potential New Bbiomarkers of Smoking Induced DNA Damage in Human Oral Tissue, 58, 581-584 (1998).

Bhaumik, M., Harris, T., Johnson, L., Guttenplan, J.B, Rogler, C., and Stanley, P., Progression of Chemically Induced Hepatoma is Severely Retarded in Mice Lacking GlcNAc on N-glycans., Cancer Res. 58, 2881-2887 (1998).

Kosinska, W., von Pressentin, M.d.M. and Guttenplan, J.B., Comparative Mutagenicity of Benzo(a)pyrene in Breast and Oral Tissues of lacZ Mice, Carcinogenesis, 20, 1103-1106 (1999).

von Pressentin, M.d.M., Kosinska, W.,, and Guttenplan, J.B. Mutagenesis Induced by Oral Carcinogens in lacZ Mouse Tongue and Other Oral Tissues, 20, 2167-2170 (1999)

Kosinska, W., von Pressentin, M.d.M. and Guttenplan, J.B.,  Mutagenesis induced by Benzo(a)pyrene in lacZ Mouse Mammary and Oral Tissues: Comparisons with Mutagenesis in Other Organs and Relationships to Previous Carcinogenicity Assays, Carcinogenesis, 20, 1103-1106 (1999).

Kosinska, W., von Pressentin, M.d.M., El Bayoumy, K. and Guttenplan, J.B., Mutagenesis by 4-Nitroquinoline-N-oxide in Oral Cavity and Esophagus in lacZ Mice and Effects of Organic Selenium Mutation Research, 466, 71-78 (2000).

Kosinska, W., von Pressentin, M.d.M. and Guttenplan, J.B. Mutagenesis by Tobacco-Specific Nitrosamines in lacZ Mice Upper Aerodigestive Tissue and Inhibition by Green Tea, Carcinogenesis, 21, 203-206 (2000)

Guttenplan, J.B., Chen, M., Kosinska, W., Zhau,Z and Cohen, L. Effects of dietary lycopene on spontaneous and benzo(a)pyrene-induced mutagenesis in the lacZ Mouse. Cancer Letters, 164, 1-6  (2001).